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Paddy, Grubble Grobble and the need for kinder childhood cancer treatments

Paddy’s imagination helped create an adventure across space. His experience of cancer shows why children urgently need treatments that are both more effective and less damaging.

An adventure imagined by Paddy

Paddy designed Grubble Grobble, a comic for Macrium about a missing Grandma and a rescue mission across space. It is a story full of imagination, adventure and the kind of big ideas that only a young creator can bring. We are hugely grateful to Paddy for sharing his world with us, and to Macrium for supporting the collaboration and helping turn his concept into a comic he can hold, share and be proud of.

A journey that changed everything

Paddy was three when he was diagnosed with Acute Lymphoblastic Leukaemia. His family was suddenly plunged into a frightening new world of treatment, uncertainty and repeated complications. During treatment, Paddy experienced serious infections, septic shock, steroid-induced psychosis and a chemotherapy-induced stroke. The stroke caused lasting neurological damage and continues to affect his mobility, spine and day-to-day care.

For Paddy’s family, diagnosis marked the beginning of a journey that did not simply end when treatment finished. Childhood was interrupted by hospital stays, painful procedures and medical trauma. Paddy’s mother describes the deep bonds formed with other families on the ward as “friendships forged in battle”—a source of love and support within an experience no family should have to face.

Paddy today

Having rung the bell, Paddy is embracing the activities he loves. He plays for Manchester United’s pan-disability football programme, reads and writes beautifully, and enjoys climbing, cycling, scootering, gymnastics and swimming. His family describes him as thoughtful, articulate and determined not to let disability prevent him from taking part. At the same time, he continues to need specialist care for the long-term effects of treatment, including severe scoliosis and weakness on the left side of his body.

Why dedicated research matters

Paddy’s story shows why survival statistics alone cannot tell the whole story. A treatment may save a child’s life while also leaving lasting physical, neurological and emotional effects. Children need therapies developed specifically for their growing bodies—treatments that are more precise, less toxic and less likely to cause lifelong harm.

Dedicated childhood cancer research can help improve survival, reduce side effects and give children a better quality of life during and after treatment. By supporting this work, you can help researchers develop kinder and more effective options for children like Paddy and for every family facing a childhood cancer diagnosis.

Lorna Fern

Dr Lorna Fern

Lorna is Senior Research Fellow & Patient Engagement Lead at the CCLG TYA Research Centre. She is also a Director at the  University College London Hospitals NHS Foundation Trust.

Lorna is an internationally recognised leader in teenage and young adult oncology, with 20 years’ research experience across academic, industry, clinical and healthcare settings. She has led a diverse research and development portfolio. Her expertise includes early diagnosis and detection, research and innovation, inequalities in access to care and research, and patient engagement. A member of the Department of Health and Social Care Children’s and Young Persons Advisory Task Force, Lorna chairs national multi-stakeholder and patient initiatives and is an invited keynote speaker, media contributor and parliamentary presenter.

Nancy Dykes

Nancy Dykes

Nancy, 11, was diagnosed with rhabdomyosarcoma when she was just 2 years old. She was treated with Proton Beam Therapy (PBT) in Germany but unfortunately relapsed less than a year later. The family were then sent to Germany for a second round of PBT. Although treatment helped to cure Nancy’s cancer, she has been left with lots of lasting effects which will require ongoing treatment throughout her life. Here Nancy and her mum, Antonia, share their story in the hope it will help others, raise awareness, and raise more money for children’s cancer research.

Prof John Hickman

Prof John Hickman

Why I am a Trustee of CCRF
 
I am a relative of the Larkin family and knew Rosie Larkin ( Friends of Rosie, now CCRF) when she had and then died of neuroblastoma, aged six. At that time, I was a scientist and professor at Manchester University, actively working on the problem of why some cancers do not die despite intensive and toxic therapies.  Seeing Rosie during her unsuccessful therapy and then attending her funeral, besides being emotional, drove me to double down on my own research as well as to support the Charity as best I could as a cancer researcher. I spent over a decade as the Chairman of the Scientific Advisory Board of the CCRF, when the Board moulded policies to ensure that funds raised for research into childhood cancers were distributed only to clinicians and researchers who had the brightest ideas that could impact of cancer medicine for children.
 
My role on the Board
 
As a Trustee,  I hope that my many decades of experience in cancer research and medicine can help the CCRF determine where best the funds that are raised can be invested in cutting edge research and medicine. I am also keen that the CCRF brings together UK and international experts in science and cancer medicine to brainstorm on how best to advance the treatment of childhood cancers.
 
My Background
 
I was a Professor of Pharmacology at Manchester University, working on drug resistance in cancer. I then moved to Paris, where I still live, to head cancer drug discovery at a French pharmaceutical company (Servier). I then headed an EU consortium for six years that brought together researchers from the pharmaceutical industry, universities and biotechnology companies, from all over Europe and the UK, to improve cancer drug discovery. I continue to be active in cancer health policy, publishing in the medical literature.
Katrina

Katrina London

Why I am a Trustee of CCRF

I have spent my professional career representing individuals and families affected by the devastating asbestos-related cancer, mesothelioma, which has no cure and for which there are only a limited number of palliative treatments available on the NHS.

I joined CCRF because I wanted to bring my understanding of the need to raise awareness of less well known cancers and passion for the need to secure improved funding for research to children facing a cancer diagnosis.

My role on the Board

I am responsible for oversight of our collaboration agreements with other charities to co-fund research into cures and treatments for childhood cancers. I also manage our challenge events and help with community fundraising. 

My Background

I am a Senior Associate at Irwin Mitchell LLP and specialise in Asbestos Disease Litigation, acting on behalf of victims of asbestos related diseases and their families.  Over the years, I have undertaken a number of fundraising challenges to raise money for cancer research, including a 1000 mile cycle ride from Glasgow to Southampton.   

Carla

Carla Nuttall

Why I’m a Trustee of CCRF
 
I became a trustee of the Children’s Cancer Research Fund because I believe every child deserves the chance to grow up healthy and with everything to look forward to in life. Like many people, I’ve seen the impact cancer can have on families and I wanted to do something that could make a real difference. This started through my work as an ambassador for Cyclists Fighting Cancer, which supported young people and their families in finding strength, confidence, and joy through movement.
 
That experience shaped my understanding of the challenges families face and the importance of community-led support – but crucially, the clear need for that to go hand-in-hand with targeted research and long-term solutions.
 
This is why I’m so passionate about the work CCRF does and proud to contribute to a cause that gives children and their families, the greatest chance of living a life without limits.
 
My Role on the Board
 
I support CCRF’s mission by bringing my experience in brand, marketing, and communications to the board. My focus is on helping CCRF tell its story in a way that resonates with people – whether that’s families, researchers, donors, or the wider public. I work alongside an incredible team to strengthen CCRF’s voice, build trust, and grow awareness so that more children and families can benefit from the breakthroughs we’re helping to fund.
 
My Background
 
I’m the Executive Director of Corporate Affairs and Marketing for The Growth Company, a social enterprise dedicated to helping people, businesses, and places to thrive through its market-leading insight, employment, skills and business support.
My passion is to help the organisations I work with to communicate with clarity, purpose, and integrity. That’s why I’ve spent my career in strategic communications supporting organisations that want to make a positive difference – CCRF could not fit my sense of purpose any better.